What's the purpose of calibers between 22 and 38?

[Rob454]

Remember that back when many of those cartridges were introduced, the average person was about 4 inches shorter and 50 pounds lighter.

Yeah but that was due to not having all sorts of fatty fast food joints on every corner of every street in America. And people walked and were not obese back then. hell these days you NEED a biggger caliber. Some of these bad guys are freaking rhinoceros size these days

[Sinixstar]

If some of these smaller rounds are so inadequate and ineffective - who's going to be the brave soul to put their money where their mouth is - and stand in front of one?