For the home user, here is what I recommend to my customers:
1. Avast--free version for home use.
2. Spyware Terminator--free, don't install the Crawler toolbar or the Clam antivirus
3. Ccleaner run on weekly basis
4. Glary Utilities run on a weekly basis.
5. JkDefrag run on a weekly basis.
6. Malwarebytes ran on a monthly basis.
Keep in mind that the Malwarebytes free version does not have a real time scanner, so use it to find anything that might have slipped through. Also, a monthly BootTime Scan with Avast is a good idea.
Probably the best thing that you can do is install Untangle on an old computer. http://www.untangle.com/ stopping the crap at the edge of your network is much better than fighting it on each computer.
1. Avast--free version for home use.
2. Spyware Terminator--free, don't install the Crawler toolbar or the Clam antivirus
3. Ccleaner run on weekly basis
4. Glary Utilities run on a weekly basis.
5. JkDefrag run on a weekly basis.
6. Malwarebytes ran on a monthly basis.
Keep in mind that the Malwarebytes free version does not have a real time scanner, so use it to find anything that might have slipped through. Also, a monthly BootTime Scan with Avast is a good idea.
Probably the best thing that you can do is install Untangle on an old computer. http://www.untangle.com/ stopping the crap at the edge of your network is much better than fighting it on each computer.

Oh, and rootkits actually come from the UNIX/Linux world. I have about 40 various Linux/UNIX systems (aside from the firewalls and other security appliances, phone systems running on Linux, etc.), and keeping them patched is quite a bit of a headache. Some make it relatively easy (Reghat, SuSE, Solaris), some are pain in the butt (specialized distros). Some release patches soon after a vulnerability is found, some take their sweet time or don't even bother releasing the patches (luckily, many patches apply across the board, or can be made to apply to other distros). There's one thing that they all have in common - the stream of patches is steady.
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