Unconfigured Ad Widget

Collapse

Regular Use of Ivermectin as Prophylaxis for COVID-19 Led Up to a 92% Reduction

Collapse
X
 
  • Time
  • Show
Clear All
new posts
  • Elgatodeacero
    Senior Member
    • Apr 2015
    • 1286

    Regular Use of Ivermectin as Prophylaxis for COVID-19 Led Up to a 92% Reduction

    Regular Use of Ivermectin as Prophylaxis for COVID-19 Led Up to a 92% Reduction in COVID-19 Mortality Rate in a Dose-Response Manner: Results of a Prospective Observational Study of a Strictly Controlled Population of 88,012 Subjects

    Background We have previously demonstrated that ivermectin used as prophylaxis for coronavirus disease 2019 (COVID-19), irrespective of the regularity, in a strictly controlled citywide program in Southern Brazil (Itajaí, Brazil), was associated with reductions in COVID-19 infection, hospitalization, and mortality rates. In this study, our objective was to determine if the regular use of ivermectin impacted the level of protection from COVID-19 and related outcomes, reinforcing the efficacy of ivermectin through the demonstration of a dose-response effect. Methods This exploratory analysis of a prospective observational study involved a program that used ivermectin at a dose of 0.2 mg/kg/day for two consecutive days, every 15 days, for 150 days. Regularity definitions were as follows: regular users had 180 mg or more of ivermectin and irregular users had up to 60 mg, in total, throughout the program. Comparisons were made between non-users (subjects who did not use ivermectin), and regular and irregular users after multivariate adjustments. The full city database was used to calculate and compare COVID-19 infection and the risk of dying from COVID-19. The COVID-19 database was used and propensity score matching (PSM) was employed for hospitalization and mortality rates. Results Among 223,128 subjects from the city of Itajaí, 159,560 were 18 years old or up and were not infected by COVID-19 until July 7, 2020, from which 45,716 (28.7%) did not use and 113,844 (71.3%) used ivermectin. Among ivermectin users, 33,971 (29.8%) used irregularly (up to 60 mg) and 8,325 (7.3%) used regularly (more than 180 mg). The remaining 71,548 participants were not included in the analysis. COVID-19 infection rate was 49% lower for regular users (3.40%) than non-users (6.64%) (risk rate (RR): 0.51; 95% CI: 0.45-0.58; p < 0.0001), and 25% lower than irregular users (4.54%) (RR: 0.75; 95% CI: 0.66-0.85; p < 0.0001). The infection rate was 32% lower for irregular users than non-users (RR: 0.68; 95% CI: 0.64-0.73; p < 0.0001). Among COVID-19 participants, regular users were older and had a higher prevalence of type 2 diabetes and hypertension than irregular and non-users. After PSM, the matched analysis contained 283 subjects in each group of non-users and regular users, between regular users and irregular users, and 1,542 subjects between non-users and irregular users. The hospitalization rate was reduced by 100% in regular users compared to both irregular users and non-users (p < 0.0001), and by 29% among irregular users compared to non-users (RR: 0.781; 95% CI: 0.49-1.05; p = 0.099). Mortality rate was 92% lower in regular users than non-users (RR: 0.08; 95% CI: 0.02-0.35; p = 0.0008) and 84% lower than irregular users (RR: 0.16; 95% CI: 0.04-0.71; p = 0.016), while irregular users had a 37% lower mortality rate reduction than non-users (RR: 0.67; 95% CI: 0.40-0.99; p = 0.049). Risk of dying from COVID-19 was 86% lower among regular users than non-users (RR: 0.14; 95% CI: 0.03-0.57; p = 0.006), and 72% lower than irregular users (RR: 0.28; 95% CI: 0.07-1.18; p = 0.083), while irregular users had a 51% reduction compared to non-users (RR: 0.49; 95% CI: 0.32-0.76; p = 0.001). Conclusion Non-use of ivermectin was associated with a 12.5-fold increase in mortality rate and a seven-fold increased risk of dying from COVID-19 compared to the regular use of ivermectin. This dose-response efficacy reinforces the prophylactic effects of ivermectin against COVID-19.
  • #2
    bigbossman
    I need a LIFE!!
    • Dec 2012
    • 11032

    If only the usual vaccine shills were still here, to tell us why this study is wrong. I could use a nice big wall of text, and maybe a few colorful charts and graphs.
    Always looking for vintage Winchester and Marlin lever action rifles. Looking to sell? Know of one for sale? Drop me a line!

    "Give a conservative a pile of bricks and you get a beautiful city. Give a leftist a city and you get a pile of bricks."

    Comment

    • #3
      tundraboomer
      Senior Member
      • Oct 2016
      • 996

      Observational study. Needs to be confirmed with a high quality clinical trial.

      Comment

      • #4
        OlderThanDirt
        FUBAR
        CGN Contributor - Lifetime
        • Jun 2009
        • 5817

        Ivermectin is dangerous and only for horses.

        In 2015, the Nobel Committee for Physiology or Medicine, in its only award for treatments of infectious diseases since six decades prior, honoured the discovery of ivermectin (IVM), a multifaceted drug deployed against some of the world's most devastating tropical diseases.
        We know they are lying, they know they are lying, they know we know they are lying, we know they know we know they are lying, but they are still lying. ~ Solzhenitsyn
        Thermidorian Reaction . . Prepare for it.

        Comment

        • #5
          Spanky8601
          Senior Member
          • Apr 2010
          • 2258

          Can someone get me an extra supply of carrots, apples and sugar cubes. I am feeling like needing a saddle.
          May I always be the type of person my dog thinks I am

          Comment

          • #6
            johncage
            Banned
            • Dec 2018
            • 993

            Originally posted by bigbossman
            If only the usual vaccine shills were still here, to tell us why this study is wrong. I could use a nice big wall of text, and maybe a few colorful charts and graphs.
            admitting that their side's active denial of anything that wasn't the officially supported script lead to untold numbers of injuries and deaths that could have otherwise been prevented by a cheap parasite medicine is going to be a hard pill to swallow

            i suspect this is going to be one of those things that people take to their graves never admitting they were wrong.

            Comment

            • #7
              ACfixer
              Calguns Addict
              • Feb 2012
              • 6053

              I've been doing the Ivermectin, zinc, D3, quercetin, C, and aspirin protocol for a year. I don't think I have even had the sniffles in that year.

              Every vaxxer around me has caught it, most multiple times. Breakthrough cases I am sure...
              Buy made in USA whenever possible.

              Comment

              • #8
                stix213
                AKA: Joe Censored
                CGN Contributor - Lifetime
                • Apr 2009
                • 18998

                It works, but leaves your throat a little horse.

                Comment

                • #9
                  ACfixer
                  Calguns Addict
                  • Feb 2012
                  • 6053

                  Originally posted by stix213
                  It works, but leaves your throat a little horse.
                  Buy made in USA whenever possible.

                  Comment

                  • #10
                    Wherryj
                    I need a LIFE!!
                    • Mar 2010
                    • 11085

                    Originally posted by tundraboomer
                    Observational study. Needs to be confirmed with a high quality clinical trial.
                    Sure, but that observational trial is screaming for further evaluation. The issue with observational trials is that there could be confounding in the groups, but this study mentions that the treated group was older, sicker and at higher risk of complications from Covid, so if anything a randomized controlled trial is likely to show an even greater benefit.
                    "What is a moderate interpretation of the text? Halfway between what it really means and what you'd like it to mean?"
                    -Antonin Scalia, Supreme Court Justice
                    "Know guns, know peace, know safety. No guns, no peace, no safety.
                    I like my guns like the left likes their voters-"undocumented".

                    Comment

                    • #11
                      Wherryj
                      I need a LIFE!!
                      • Mar 2010
                      • 11085

                      Originally posted by johncage
                      admitting that their side's active denial of anything that wasn't the officially supported script lead to untold numbers of injuries and deaths that could have otherwise been prevented by a cheap parasite medicine is going to be a hard pill to swallow

                      i suspect this is going to be one of those things that people take to their graves never admitting they were wrong.
                      Well, this is getting written into enforceable law. CA just passed a bill making any "Covid disinformation" a MANDATORY action by the Medical Board of CA.

                      For all the left's screaming about totalitarianism and fascism on the right, the left certainly does seem to hold the monopoly on such political ideologies.
                      "What is a moderate interpretation of the text? Halfway between what it really means and what you'd like it to mean?"
                      -Antonin Scalia, Supreme Court Justice
                      "Know guns, know peace, know safety. No guns, no peace, no safety.
                      I like my guns like the left likes their voters-"undocumented".

                      Comment

                      • #12
                        Scota4570
                        Senior Member
                        • Sep 2006
                        • 1719

                        Studies are not done on drugs that are not profitable. A real study is needed to place a drug in the formulary that is extremely expensive. The idea is is to make lots of money. Why would they invest money that will not see back in profit?

                        Your health is not relevant.

                        Comment

                        • #13
                          stonefly-2
                          Veteran Member
                          • Mar 2013
                          • 4993

                          Guys, I took his post to be sardonic.
                          What do you call the people that abandoned the agenda of John Kennedy and adopted the agenda of Lee Oswald?

                          Pronouns: "Dude" and "Playa".

                          https://billstclair.com/Unintended-Consequences.pdf


                          I was born under a wandrin star.

                          Comment

                          Working...
                          UA-8071174-1