New ADE study is not good

[stix213]

To the naysayers, I brought a real published study this time.

https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext

Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors).

Translation: Current vaccines are much more at risk of resulting in antibody dependent enhancement when the vaccinated person is exposed to the delta variant than if they were exposed to the original strain.

And people are wondering why so many vaccinated are coming down with delta......

[sd_shooter]

Thanks, bookmarked

[anthonyca]

There is a reason vaccines have always gone through Ling trials, often over a decade. Why is these vaccines being pushed through so quickly without even making it out ofnthe trials?

[sd_shooter]

There is a reason vaccines have always gone through Ling trials, often over a decade. Why is these vaccines being pushed through so quickly without even making it out ofnthe trials?

It was a unique opportunity for the globalists to seize more power and control.

[Henry Shooter]

I’m no scientist or anyone special
But,
No Kidding.
Natural progression of a virus against an antibody.
Who’da Thunk It?

[Dan_Eastvale]

These idiots are so committed to this "vaccine" that even if it showed 10% will either die or receive permanent damage from it they will still mandate it.

[as_rocketman]

To the naysayers, I brought a real published study this time.

https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext

Translation: Current vaccines are much more at risk of resulting in antibody dependent enhancement when the vaccinated person is exposed to the delta variant than if they were exposed to the original strain.

And people are wondering why so many vaccinated are coming down with delta......

This is a letter to the editor, not a full paper. (Full Text) Your summary, bolded above, is not accurate at all.

The paper only shows a possible mechanism based on results from an in silico study, nothing at all confirmed in real-world results. Given that the Delta strain is now dominant in several countries with high vaccination rates, and those countries continue to show substantial protective immunity, I think we can safely say the model system described here is oversimplified.

It also is not at all clear the ADE effect, if it were real, would only apply to vaccinated immunity and not to natural immunity. That can happen too.

Anyway, thanks for the paper and this is a real concern -- but it falls well short of confirming speculative concerns about our current vaccines. This is also not the kind of result that would be avoided with a longer vaccine safety study.

[DaveInOroValley]

Glad I had it back when it all started and no one knew what it was.

[ibanezfoo]

This is a letter to the editor, not a full paper. (Full Text) Your summary, bolded above, is not accurate at all.

The paper only shows a possible mechanism based on results from an in silico study, nothing at all confirmed in real-world results. Given that the Delta strain is now dominant in several countries with high vaccination rates, and those countries continue to show substantial protective immunity, I think we can safely say the model system described here is oversimplified.

It also is not at all clear the ADE effect, if it were real, would only apply to vaccinated immunity and not to natural immunity. That can happen too.

Anyway, thanks for the paper and this is a real concern -- but it falls well short of confirming speculative concerns about our current vaccines. This is also not the kind of result that would be avoided with a longer vaccine safety study.

What?

[sd_shooter]

What?

Yeah we're going to need a peer-reviewed paper or study to show where Delta dominates and everyone's vaxxed - yet safe!

[ibanezfoo]

Yeah we're going to need a peer-reviewed paper or study to show where Delta dominates and everyone's vaxxed - yet safe!

I'd like to see some proof the delta exists and how they know all these "infections" are actually delta...

[PHenry2015]

This is a letter to the editor, not a full paper. (Full Text) Your summary, bolded above, is not accurate at all.

The paper only shows a possible mechanism based on results from an in silico study, nothing at all confirmed in real-world results. Given that the Delta strain is now dominant in several countries with high vaccination rates, and those countries continue to show substantial protective immunity, I think we can safely say the model system described here is oversimplified.

It also is not at all clear the ADE effect, if it were real, would only apply to vaccinated immunity and not to natural immunity. That can happen too.

Anyway, thanks for the paper and this is a real concern -- but it falls well short of confirming speculative concerns about our current vaccines. This is also not the kind of result that would be avoided with a longer vaccine safety study.

Wrong, dude. It's an "Articles in Press." See the URL that shows "articles". "Letter to the Editor" is a separate link. Reading is fundamental.

[Sgt. J Beezy]

I'd like to see some proof the delta exists and how they know all these "infections" are actually delta...

[as_rocketman]

Yeah we're going to need a peer-reviewed paper or study to show where Delta dominates and everyone's vaxxed - yet safe!

I've already cited that for you, but here it is again:

Campbell et al.

With the BNT162b2 vaccine, the effectiveness of two doses was 93.7% (95% CI, 91.6 to 95.3) among persons with the alpha variant and 88.0% (95% CI, 85.3 to 90.1) among those with the delta variant. With the ChAdOx1 nCoV-19 vaccine, the effectiveness of two doses was 74.5% (95% CI, 68.4 to 79.4) among persons with the alpha variant and 67.0% (95% CI, 61.3 to 71.8) among those with the delta variant.

This compares the Pfizer and AstraZeneca vaccines, and "effectiveness" here is defined as prevention of symptomatic infection, not any detectable infection.

Yes, protective immunity is down with the new variant, surprising no one, and it will probably decrease a bit more as the virus continues to evolve. However, this result flatly contradicts any emergence of antibody-dependent enhancement against the Delta strain.

[balgor]

ADE in theory would increase the severity of disease in vaccinated populations.


If ADE was a problem, we'd see MORE hospitalized vaccinated covid patients than unvaccinated covid patients, we are in fact seeing the EXACT OPPOSITE. Most of the patients hospitalized with C19 are unvaccinated period.