NO POLITICS The SARS-CoV2 Science-Based Discussion Thread

[capo]

https://archive.is/ONUmi

comments?

[stonefly-2]

Thought this was interesting..




https://www.google.com/url?sa=t&rct=...7Ck0zkTKWDoFP4

Naw,

it was proclaimed early on that treating a viral infection with antihistamines and antacids is ludicrous.

[SW1917]

People seem to be under the belief that there is a federal SIP order - no such thing. All these orders are state by state - the feds have SUGGESTED a number of actions but have not issued anything other than the emergency decoration



43 states now have stay-at-home orders for coronavirus. These are the 7 that don't.

https://www.cbsnews.com/news/stay-at-home-orders-states/

Arkansas
Iowa
Nebraska
North Dakota
South Dakota
Utah
Wyoming

[Doheny]

Can we sticky this thread so it stays at the top?

[DJD100]

Thank you for this intelligent thread, much appreciated vs the others here!

What's the latest on ACE Inhibitors and COVID-19?

[cleonard]

Thank you for this intelligent thread, much appreciated vs the others here!

What's the latest on ACE Inhibitors and COVID-19?

A non reviewed Chinese study.

https://www.medrxiv.org/content/10.1101/2020.03.31.20038935v1.full.pdf

It basically says to continue the drugs if you are already on them. Being on both a ARB and a ACE inhibitor is best.

The study was rather small.

There are larger trials underway. Hopefully we get some results with it taking months.

[DJD100]

A non reviewed Chinese study.

https://www.medrxiv.org/content/10.1101/2020.03.31.20038935v1.full.pdf

It basically says to continue the drugs if you are already on them. Being on both a ARB and a ACE inhibitor is best.

The study was rather small.

There are larger trials underway. Hopefully we get some results with it taking months.

Thanks, much appreciated!

[FireCloud9]

Roche's Actemra COVID-19 experimental immunosuppressive drug trial looks promising.

[smashycrashy]

They traced a patient infecting 9 others in a restaurant in China, thought it was interesting

https://wwwnc.cdc.gov/eid/article/26/7/20-0764_article

[RNursejitsu7]

what's the consensus on this disease being airborne vs droplet transmitted?

[jwkincal]

UV Sterilization via Sunlight

Here's a NIH paper worked up for the DoD (with obvious Bioweapon applications) for the efficacy of sunlight as a UV source for sterilization:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280232/#r79

Coronaviruses are listed as a genus, so not broken down by individual genotype. Still, the information is useful if you are taking an engineering approach (figure out 2x or 3x the estimated exposure to produce a thousand-fold reduction in generic coronavirus, use that as your baseline).

I'd say that the communicability of CARS-CoV-2 in climates with significant solar exposure (i.e. most of the SW US) will be substantially reduced as the summer comes on.

24-72 hours on a surface in the lab is one thing, in the wash of UV radiation from the July sun in San Fernando, those microbes are never going to last that long.

[freespool]

The doc leading Covid-19 clinical trials at UCSF gives an overview of studies and prospects for various therapies, towards the latter half of the video. She says so far there's nothing to show any benefit of HCQ, nor remdesivir, from controlled trials, though decent safety profiles at least. The statistician George Rutherford is also pretty good, but doesn't feature all that much in this edition. Some discussion of imminent contact tracing plans in SF. The previous edition, from 5 days ago, has some good stuff too, including a detailed presentation by Mike Reid, the guy who is leading the contact tracing initiative, and apparently has the ear of the state politicians as well, so worth finding out what they are planning (it's the phone and shoe leather strategy, not the tracking device plan).

Play it at 1.25X speed.

https://www.youtube.com/watch?v=o1I2KlWPw9I

[sakosf]

https://www.jpost.com/HEALTH-SCIENCE/Coronavirus-has-mutated-into-at-least-30-different-strains-new-study-finds-625333

Their research report still needs peer review to be conclusive I think.

[capo]

journal article on the likely origins and notable spike protein novelty in SARS-CoV2. Conclusion quoted below.

In the midst of the global COVID-19 public-health emergency, it is reasonable to wonder why the origins of the pandemic matter. Detailed understanding of how an animal virus jumped species boundaries to infect humans so productively will help in the prevention of future zoonotic events. For example, if SARS-CoV-2 pre-adapted in another animal species, then there is the risk of future re-emergence events. In contrast, if the adaptive process occurred in humans, then even if repeated zoonotic transfers occur, they are unlikely to take off without the same series of mutations. In addition, identifying the closest viral relatives of SARS-CoV-2 circulating in animals will greatly assist studies of viral function. Indeed, the availability of the RaTG13 bat sequence helped reveal key RBD mutations and the polybasic cleavage site.

The genomic features described here may explain in part the infectiousness and transmissibility of SARS-CoV-2 in humans. Although the evidence shows that SARS-CoV-2 is not a purposefully manipulated virus, it is currently impossible to prove or disprove the other theories of its origin described here. However, since we observed all notable SARS-CoV-2 features, including the optimized RBD and polybasic cleavage site, in related coronaviruses in nature, we do not believe that any type of laboratory-based scenario is plausible.

More scientific data could swing the balance of evidence to favor one hypothesis over another. Obtaining related viral sequences from animal sources would be the most definitive way of revealing viral origins. For example, a future observation of an intermediate or fully formed polybasic cleavage site in a SARS-CoV-2-like virus from animals would lend even further support to the natural-selection hypotheses. It would also be helpful to obtain more genetic and functional data about SARS-CoV-2, including animal studies. The identification of a potential intermediate host of SARS-CoV-2, as well as sequencing of the virus from very early cases, would similarly be highly informative. Irrespective of the exact mechanisms by which SARS-CoV-2 originated via natural selection, the ongoing surveillance of pneumonia in humans and other animals is clearly of utmost importance.

https://www.nature.com/articles/s41591-020-0820-9

[freespool]

journal article on the likely origins and notable spike protein novelty in SARS-CoV2. Conclusion quoted below.

Really interesting paper. Are you convinced by their dismissive statements about the prospects for human manipulation origin? I don't know enough to see much beyond what they are saying, but it seems their estimation is pretty leashed to the idea that the virus would be obviously Frankensteinian if it were cell or animal-passage derived. Aside from that specific implication, they also dismiss the polybasic insertion that may confer pathogenicity as evidence of monster-making, while at the same time describing how it has yet to be found in nature for this virus sub-type, and can be created in influenza by just those techniques.