Suggestions
Of the guns you mentioned, I would tend to go with the H&K USP in 9mm. These days 9mm ammo is easier to find (and cheaper) than .380, and if the gun will do double duty as a defensive weapon, 9mm is a more potent choice than .22. The recoil of 9mm in a full size gun is also fairly mild, and should not inhibit learning to shoot.
Unless you are going to carry a gun such that weight is important, I don't see much point in polymer except to keep the manufacturing cost down compared to metal. So if this gun is just for range and home defense, you might consider the metal frame alternatives to the polymer USP as well. That would bring such brands as Sig and CZ into consideration. My favorite for a 9mm metal framed gun would be the Sig P226 (full size) or the more compact Sig P228.
Of the guns you mentioned, I would tend to go with the H&K USP in 9mm. These days 9mm ammo is easier to find (and cheaper) than .380, and if the gun will do double duty as a defensive weapon, 9mm is a more potent choice than .22. The recoil of 9mm in a full size gun is also fairly mild, and should not inhibit learning to shoot.
Unless you are going to carry a gun such that weight is important, I don't see much point in polymer except to keep the manufacturing cost down compared to metal. So if this gun is just for range and home defense, you might consider the metal frame alternatives to the polymer USP as well. That would bring such brands as Sig and CZ into consideration. My favorite for a 9mm metal framed gun would be the Sig P226 (full size) or the more compact Sig P228.

For those of use with smaller hands, the 226 and 1911 are great choices!
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