Hydroxychloroquine RCT Study Published in The British Medical Journal shows no effect

[balgor]

https://www.bmj.com/content/369/bmj.m1849?utm_source=twitter&utm_medium=social&utm_term=hootsuite&utm_content=sme&utm_campaign=usage

Conclusions Administration of hydroxychloroquine did not result in a significantly higher probability of negative conversion than standard of care alone in patients admitted to hospital with mainly persistent mild to moderate covid-19. Adverse events were higher in hydroxychloroquine recipients than in non-recipients.

Small sample, but an actual RCT and published in the BMJ a peer reviewed top flight journal. We can't say for certain that Hydroxychloroquine is useless or useful, but the evidence is coalescing around the useless outcome. There are more RCTs coming out soon, so we'll see. I'm keeping an open mind. I don't care if a drug is being touted by Kim Jong Il, if an RCT shows its effective against Covid-19 I'm all for mass usage.

Come on Minnesota, publish this study, estimated completion date was May, 14th:

https://clinicaltrials.gov/ct2/show/NCT04308668

FYI on RCTs:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235704/

[SAN compnerd]

https://www.bmj.com/content/369/bmj....campaign=usage

Conclusions Administration of hydroxychloroquine did not result in a significantly higher probability of negative conversion than standard of care alone in patients admitted to hospital with mainly persistent mild to moderate covid-19. Adverse events were higher in hydroxychloroquine recipients than in non-recipients.

Small sample, but an actual RCT and published in the BMJ a peer reviewed top flight journal. We can't say for certain that Hydroxychloroquine is useless or useful, but the evidence is coalescing around the useless outcome. There are more RCTs coming out soon, so we'll see. I'm keeping an open mind. I don't care if a drug is being touted by Kim Jong Il, if an RCT shows its effective against Covid-19 I'm all for mass usage.

Come on Minnesota, publish this study, estimated completion date was May, 14th:

https://clinicaltrials.gov/ct2/show/NCT04308668

FYI on RCTs:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235704/

Study performed in China is Chinese propaganda. Worthless even with the Brit's seal of approval. Also of note is there is lots of solid science saying that erythromycin and or zinc is key to efficacy.

[cleonard]

I'd like to see a study where the treatment was started closer to the onset of symptoms. In this one the average delay was 16 days. Most of the positive anecdotal reports were from patients with less delay before treatment.

There are other viral treatments that only work when given early. A prime example it Tamiflu. It really only helps if given within 48 hours of the onset of symptoms. It does little for someone who gets flu complications and ends up in the hospital with pneumonia. The time for it to help the patient has passed by then. I know that the flu is completely different, but I wonder if the same kind of "it only works if given promptly" applies to Covid and HCQ.

The other issue is that this was a Chinese study and not everyone has a lot of trust with the Chinese government these days.

There are a lot of other trials going on. HCQ is not the only existing drug being tested. There are several others that showed in vitro promise. I sure hope that at least one of them turns out to be a viable treatment. I don't root for one drug over another. HCQ has just received more press coverage.
I'm just rooting for at least one to show positive results in a controlled trial.

Having an effective or at least partially effective treatment would help a lot.

[Den60]

Seems to be a study aimed at attacking President Trump. China isn't liking him right now. As I understand the HCQ issue it needs to be used in combination with Z-pac and zinc in order to be effective. Someone posted something from a college in VA that did some research and even came up with a combination of things like Vitamin C, Zinc, and other things that may have some effectiveness as a prophylactic as well as a therapeutic. I have been following that recommendation. Can't hurt.

[kelvin232]

Title is misleading. It wasn't 'no effect'... It shows NEGATIVE effect.

[Funbaby]

But Dear Leader said it was a gift from god.

Dear Leader is infallible.

[seal20]

You guys don't even read the articles you praise as fitting your agenda...

What a bunch of WEAK TRUCKS

[AlienHobo]

Posted up today.

[CaliforniaCowboy]

From what I read, in yet another study and no I do not have the link as I do not remember where I read it.

The effectivness of HCH was very slight or not helpful at all in patients that were already exibiting serious complications, thus those that had to be admitted to a stay in the hospital. But that the drug was very effective in those that had not yet gotten to that point. So the drug seems to be effective if you can get it to the patient before the virus progresses too far. So it would be something you would want to prescribe to those that have tested positive with mild early symptoms.

Many of the studies on the drug were being done on people in bad shape already, So they would give some people with severe symptoms the drug and some with severe symptoms did not get the drug. So you would not see any real difference in outcomes as the drug is not effective if not given before a patient gets to that severity to begin with.

[CaliforniaCowboy]

But Dear Leader said it was a gift from god.

Dear Leader is infallible.

Dear Leader is not coming up with that info on his own, he is relaying what the so called "Scientific Experts" are reporting to him.

[balgor]

Dear Leader is not coming up with that info on his own, he is relaying what the so called "Scientific Experts" are reporting to him.

The whitehouse pulled the info on HCQ directly from Fox news, who pulled it from the random french doctor. The general consensus amongst the actual scientific community on HCQ was that the effects on Covid-19 were unknown, no where near worth the Trumpian hype, and HCQ had well known mild toxicities.

[sigstroker]

Tell that to Michigan state Rep. Karen Whitsett.