I usually gravitate to the 4-inch guns or "duty guns" as I call them.
The Six-inchers are good for longer distance shooting. I figure with a 4-inch revolver, I can hit out to 25 yards well enough and I can, with a few seconds aim, make defensive hits at 50 yards with a .357. If I need any more distance than about 40 yards -- or more power than the .357 at that range -- I'll reach for the 12-gauge or a rifle.
Now, if I spent almost all my outdoors time in the mountains or on open range land, I might select a 6-inch (5-inch would be better IMO) for the extra range and sight radius.
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