I better start looking at the .357mag VS .45+p.
If you believe the math, .357mag hits harder than .45, even plus P.
With exotics and handloading, anything is possible, but I do think most .45 were designed for 230@800 FPS, .357 200@1200. If I can get expanding bullets (to expand), I think the .357 is better.
.44 mag and the bigger newer calibers are the best........and someday I will have them. Until then, I do have some handguns that will make the bear blink