Long Beach also has a very easy to use airport. OC/John Wayne is nice but expensive to fly into.
A weekend mabe be easiest, Socal members are so spread out and week day traffic is just so brutal.
Some place off the 210 maybe near Pasadena might be good. Gives easy access for folks from Riverside/San Berdo (since the 210 now goes all the way through), LA County and OC. Plenty of other freeway choices