There are tons of opinions on this topic and i can only offer my thought.
1. If all I could reach or what was easiest to reach was a fully loaded 22LR, I would grab it and use it.
2. If I had a choice between grabbing a 22LR vs a shotgun or pistol in high caliber, I would reach for the shoutgun or pistol or carbine rifle
If you need to think it through to plan the right caliber and ammo combo, follow the link. They FBI has a very intense test criteria, please consider in your choice your living location (apartment, condo, other, cave) in the decision. You do not want over penetration.
FBI Ammo Penetration test Criteria
Here to help
Jacob Rascon, (aka) Pennys Dad
CALGUNS Shooting Sports Association.
1. Blessed be the LORD my Rock, Who trains my hands for war, And my fingers for battle 2. My loving-kindness and my fortress, My high tower and my deliverer, My shield and the One in whom I take refuge, Who subdues my people under me.