Loading for a buddy's Kimber 300 Win. Mag. using the Barnes 168 TTSX, I used between 76-79 grains of RE-22 in new Winchester brass and used a Federal 215 primer. Be sure to check published data before starting.
I loaded it to just under max. COL. for reliable feeding from the magazine. It shot around 1 MOA out to 300 yards. You'll need to work up the load for your rifle. RE-22 shot better than 4831 and RE-19 in his rifle. I didn't have a chrono to check the velocity, but it should be in the 3000 +FPS range.
Just be aware some RE-22 users have reported RE-22 being temperature sensitive.
I like the new Tipped TSX bullets over the original TSX.